Strategic Design of Antimicrobial Hydrogels Containing Biomimetic Additives for Enhanced Matrix Responsiveness and HDFa Wound Healing Rates.
Abigail N LinhartKatherine M Wortman-OttoIan DeningerAbigail L DudekHeather R LangeDany M DanhausenCarolyn F GraversonThomas J BeckmannMallory A HavensJason J KeleherPublished in: ACS applied bio materials (2020)
Supramolecular nanocomposite materials have emerged as a leading interdisciplinary research area that exploits synergistic relationships at the nanoscale to enhance the properties (mechanical and chemical) of next-generation biopolymeric materials. Hydrogels synthesized from natural biopolymers have emerged because of their intrinsic properties such as noncytotoxicity and biodegradability as well as their well-defined three-dimensional, noncovalent network that is ideal for modification and functionalization. Therefore, it is critical to develop a mechanistic understanding tailored to the nuances involved in the interactions of the biopolymer scaffold with the functional additives present in these complex matrixes. This work will discuss the strategic design of hydrogels placing emphasis on the selection of the biopolymer network and the critical role that the incorporation of additives such as biomimetic cross-linking agents (lactones/amino acids) and antimicrobial nanoparticles (NPs) has on the properties and responsiveness of the final nanocomposite. Results have shown that the hydrogen bonding capacity of the biomimetic additives and antimicrobial agents (i.e., AgNPs) impacts the packing density of the hydrogel network and therefore modulates the resultant swellability. Furthermore, the addition of Ag-coated TiO 2 NPs (Ag/TiO 2 NPs) and biomimetic additives provided antimicrobial activity along with enhanced closure rates of simulated wounds in adult human dermal fibroblasts.
Keyphrases
- tissue engineering
- wound healing
- quantum dots
- visible light
- ionic liquid
- staphylococcus aureus
- drug delivery
- hyaluronic acid
- extracellular matrix
- highly efficient
- oxide nanoparticles
- endothelial cells
- amino acid
- reduced graphene oxide
- gold nanoparticles
- energy transfer
- smoking cessation
- cancer therapy
- solid phase extraction
- childhood cancer
- liquid chromatography
- mass spectrometry
- pluripotent stem cells