Methodological aspects of a randomized within-patient concurrent controlled design for clinical trials in spine surgery.
A Mechteld LehrWilco Ch JacobsRebecca K StellatoRené M CasteleinF Cumhur OnerMoyo C KruytPublished in: Clinical trials (London, England) (2022)
When suitable, the randomized within-patient controlled trial is an efficient design that provides a solution to some of the considerable challenges of a classic randomized controlled trial in (spine) surgery. This design holds specific promise for efficacy studies of non-active bone grafts in instrumented posterolateral fusion surgery.