Growth Factor Concentrate (GFC) for the Management of Osteoarthritis of the Knee: A Systematic Review.
Ashim GuptaNicola MaffulliPublished in: Indian journal of orthopaedics (2024)
Intra-articular administration of GFC is safe and potentially efficacious to manage OA of the knee. More, adequately powered, multi-center, prospective, RCTs are warranted to demonstrate the long-term effectiveness of GFC in patients suffering from mild-to-moderate knee OA and to justify its routine clinical use. Further studies evaluating the efficacy of GFC compared to other orthobiologics are also required to allow physicians/surgeons to choose the optimal orthobiologic for the treatment of OA of the knee.
Keyphrases
- knee osteoarthritis
- total knee arthroplasty
- growth factor
- anterior cruciate ligament
- end stage renal disease
- ejection fraction
- chronic kidney disease
- randomized controlled trial
- primary care
- newly diagnosed
- systematic review
- peritoneal dialysis
- rheumatoid arthritis
- quality improvement
- prognostic factors
- clinical practice
- combination therapy
- smoking cessation