Tumour infiltrating lymphocytes and immune-related genes as predictors of outcome in pancreatic adenocarcinoma.

Alberto D'AngeloNavid SobhaniGiandomenico RovielloStefan BagbyDeborah BonazzaCristina BottinFabiola GiudiciFabrizio ZanconatiNicolo De ManziniAlessandra GuglielmiDaniele Generali

Published in: PloS one (2019)

Tumour infiltrating lymphocytes were present at higher levels in samples from patients with better prognosis. Our findings indicate that tumour infiltrating lymphocyte levels and expression level of the immune system genes listed above influence pancreatic ductal adenocarcinoma prognosis. This information could be used to improve selection of best responders to immune inhibitors.

Keyphrases

peripheral blood
poor prognosis
genome wide
healthcare
gene expression
binding protein
health information
transcription factor
bioinformatics analysis