Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas.

Jordan A Stinson Allison Sheen Noor Momin Jordan Hampel Rebecca Bernstein Rebecca L Kamerer Bahaa Fadl-Alla Jonathan P Samuelson Elizabeth Fink Timothy M Fan Karl Dane Wittrup

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These results support the safety and activity of intratumorally-delivered, collagen-anchoring cytokines for inflammatory polarization of the canine soft tissue sarcoma tumor microenvironment. We are further evaluating the efficacy of this approach in additional canine cancers, including oral malignant melanoma.

Keyphrases

soft tissue
wound healing
high grade