Karl Dane Wittrup (K Dane Wittrup, K Dane Wittrup)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 34

Top Venues

Nature communications

Cancer immunology research

ACS synthetic biology

Clinical cancer research : an official journal of the American Association for Cancer Research

California Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

California Institute of Technology Sep 01 1984 - Aug 01 1988

United States

PHD :: Chemical Engineering

University of New Mexico Sep 01 1980 - May 30 1984

United States

BSC :: Chemical Engineering

Publications

Naveen K Mehta, Kavya Rakhra, Kristan A Meetze, Bochong Li, Noor Momin, Jason Y H Chang, Karl Dane Wittrup, Patrick A Baeuerle, Jennifer S Michaelson
CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity. Cancer immunology research 12 (8) (2024)
Naveen K Mehta, Kavya Rakhra, Kristan A Meetze, Bochong Li, Noor Momin, Jason Y H Chang, Karl Dane Wittrup, Patrick A Baeuerle, Jennifer S Michaelson
CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity. Cancer immunology research (2024)
Naveen K Mehta, Kavya Rakhra, Kristan A Meetze, Bochong Li, Noor Momin, Jason Y H Chang, Karl Dane Wittrup, Patrick A Baeuerle, Jennifer S Michaelson
CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity. Cancer immunology research 12 (8) (2024)
Jordan A Stinson, Matheus Moreno P Barbosa, Allison Sheen, Noor Momin, Elizabeth Fink, Jordan Hampel, Kimberly A Selting, Rebecca L Kamerer, Keith L Bailey, Karl Dane Wittrup, Timothy M Fan
Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Megan Hoffman, Keith Ming Hong Cheah, Karl Dane Wittrup
A Novel Gain-of-Signal Assay to Detect Targeted Protein Degradation. ACS synthetic biology 13 (1) (2024)
Naveen K Mehta, Kavya Rakhra, Kristan A Meetze, Bochong Li, Noor Momin, Jason Y H Chang, Karl Dane Wittrup, Patrick A Baeuerle, Jennifer S Michaelson
CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity. Cancer immunology research 12 (8) (2024)
Megan Hoffman, Keith Ming Hong Cheah, Karl Dane Wittrup
A Novel Gain-of-Signal Assay to Detect Targeted Protein Degradation. ACS synthetic biology 13 (1) (2024)
Megan Hoffman, Keith Ming Hong Cheah, Karl Dane Wittrup
A Novel Gain-of-Signal Assay to Detect Targeted Protein Degradation. ACS synthetic biology (2024)
Megan Hoffman, Keith Ming Hong Cheah, Karl Dane Wittrup
A Novel Gain-of-Signal Assay to Detect Targeted Protein Degradation. ACS synthetic biology 13 (1) (2024)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs. Nature communications 15 (1) (2024)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs. Nature communications 15 (1) (2024)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs. Nature communications 15 (1) (2024)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs. Nature communications 15 (1) (2024)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs. Nature communications 15 (1) (2024)
Jordan A Stinson, Matheus Moreno P Barbosa, Allison Sheen, Noor Momin, Elizabeth Fink, Jordan Hampel, Kimberly A Selting, Rebecca L Kamerer, Keith L Bailey, Karl Dane Wittrup, Timothy M Fan
Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Luciano Santollani, Karl Dane Wittrup
Spatiotemporally programming cytokine immunotherapies through protein engineering. Immunological reviews (2023)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
Tregs constrain CD8 + T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy. bioRxiv : the preprint server for biology (2023)
Zachariah P Tritz, Katayoun Ayasoufi, Delaney M Wolf, Carley A Owens, Courtney S Malo, Benjamin T Himes, Cori E Fain, Emma N Goddery, Lila T Witt, Fang Jin, Michael J Hansen, Ian F Parney, Chensu Wang, Kelly D Moynihan, Darrell J Irvine, Karl Dane Wittrup, Rosa M Diaz Marcano, Richard G Vile, Aaron J Johnson
Anti-PD-1 and extended half-life-IL-2 synergize for treatment of murine glioblastoma independent of host MHC Class I expression. Cancer immunology research (2023)
Jordan A Stinson, Allison Sheen, Noor Momin, Jordan Hampel, Rebecca Bernstein, Rebecca L Kamerer, Bahaa Fadl-Alla, Jonathan P Samuelson, Elizabeth Fink, Timothy M Fan, Karl Dane Wittrup
Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Joseph R Palmeri, Brianna M Lax, Joshua M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, Emi A Lutz, William Pinney, Bryan D Bryson, Karl Dane Wittrup
Tregs constrain CD8 + T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy. bioRxiv : the preprint server for biology (2023)
Daniel R Schmidt, Iva Monique T Gramatikov, Allison Sheen, Christopher L Williams, Martina Hurwitz, Laura E Dodge, Edward Holupka, W S Kiger, Milton R Cornwall-Brady, Wei Huang, Howard H Mak, Kathleen S Cormier, Charlene Condon, Karl Dane Wittrup, Ömer H Yilmaz, Mary Ann Stevenson, Julian D Down, Scott R Floyd, Jatin Roper, Matthew G Vander Heiden
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer. Communications medicine 3 (1) (2023)
Brianna M Lax, Joseph R Palmeri, Emi A Lutz, Allison Sheen, Jordan A Stinson, Lauren Duhamel, Luciano Santollani, Alan Kennedy, Adrienne M Rothschilds, Stefani Spranger, David Michael Sansom, Karl Dane Wittrup
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies. Proceedings of the National Academy of Sciences of the United States of America 120 (31) (2023)
Emi A Lutz, Noor Jailkhani, Noor Momin, Ying Huang, Allison Sheen, Byong H Kang, Karl Dane Wittrup, Richard O Hynes
Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice. PNAS nexus 1 (5) (2022)
Yash Agarwal, Lauren E Milling, Jason Y H Chang, Luciano Santollani, Allison Sheen, Emi A Lutz, Anthony Tabet, Jordan Stinson, Kaiyuan Ni, Kristen A Rodrigues, Tyson J Moyer, Mariane B Melo, Darrell J Irvine, Karl Dane Wittrup
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity. Nature biomedical engineering 6 (2) (2022)
Emi A Lutz, Yash Agarwal, Noor Momin, Sarah C Cowles, Joseph R Palmeri, Ellen Duong, Vladlena Hornet, Allison Sheen, Brianna M Lax, Adrienne M Rothschilds, Darrell J Irvine, Stefani Spranger, Karl Dane Wittrup
Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies. Proceedings of the National Academy of Sciences of the United States of America 119 (36) (2022)
Emi A Lutz, Noor Jailkhani, Noor Momin, Ying Huang, Allison Sheen, Byong H Kang, Karl Dane Wittrup, Richard O Hynes
Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice. PNAS nexus 1 (5) (2022)
Noor Momin, Joseph R Palmeri, Emi A Lutz, Noor Jailkhani, Howard Mak, Anthony Tabet, Magnolia M Chinn, Byong Ha Kang, Virginia Spanoudaki, Richard O Hynes, Karl Dane Wittrup
Maximizing response to intratumoral immunotherapy in mice by tuning local retention. Nature communications 13 (1) (2022)
Brendan L Horton, Duncan M Morgan, Noor Momin, Maria Zagorulya, Elen Torres-Mejia, Vidit Bhandarkar, Karl Dane Wittrup, John Christopher Love, Stefani Spranger
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non-small cell lung cancer. Science immunology 6 (64) (2021)
Byong H Kang, Noor Momin, Kelly D Moynihan, Murillo Silva, Yingzhong Li, Darrell J Irvine, Karl Dane Wittrup
Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice. PloS one 16 (4) (2021)
Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming. Nature communications 12 (1) (2021)
Naveen K Mehta, Roma V Pradhan, Ava P Soleimany, Kelly D Moynihan, Adrienne M Rothschilds, Noor Momin, Kavya Rakhra, Jordi Mata-Fink, Sangeeta N Bhatia, Karl Dane Wittrup, Darrell J Irvine
Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines. Nature biomedical engineering 4 (6) (2020)
Leyuan Ma, Tanmay Dichwalkar, Jason Y H Chang, Benjamin Cossette, Daniel Garafola, Angela Q Zhang, Michael Fichter, Chensu Wang, Simon Liang, Murillo Silva, Sudha Kumari, Naveen K Mehta, Wuhbet Abraham, Nikki Thai, Na Li, Karl Dane Wittrup, Darrell J Irvine
Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor. Science (New York, N.Y.) 365 (6449) (2020)
Noor Momin, Naveen K Mehta, Nitasha R Bennett, Leyuan Ma, Joseph R Palmeri, Magnolia M Chinn, Emi A Lutz, Byong Ha Kang, Darrell J Irvine, Stefani Spranger, Karl Dane Wittrup
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Science translational medicine 11 (498) (2020)
Byron H Kwan, Eric F Zhu, Alice Tzeng, Harun R Sugito, Ahmed A Eltahir, Botong Ma, Mary K Delaney, Patrick A Murphy, Monique J Kauke, Alessandro Angelini, Noor Momin, Naveen K Mehta, Alecia M Maragh, Richard O Hynes, Glenn Dranoff, Jennifer R Cochran, Karl Dane Wittrup
Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. The Journal of experimental medicine 214 (6) (2017)

Karl Dane Wittrup.css-eqlu8i{font-size:small;padding-left:4px;} (K Dane Wittrup, K Dane Wittrup)

Publication Activity (10 Years)

Top Topics

Top Venues

Karl Dane Wittrup (K Dane Wittrup, K Dane Wittrup)