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The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China.

Ye XuYing ZhangXiangkuo ZhengKaihang YuYao SunWenli LiaoHuaiyu JiaChunquan XuZhexiao MaMo Shen
Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2021)
Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa. This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP-like genes in 228 P. aeruginosa was 25.4% (58/228), and 6 new crpP-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of crpP-positive was diverse. Furthermore, the mean expression level of crpP was no statistical difference between fluoroquinolone-susceptible and -resistant group (P > 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in P. aeruginosa.
Keyphrases
  • pseudomonas aeruginosa
  • genome wide
  • cystic fibrosis
  • poor prognosis
  • copy number
  • risk factors
  • biofilm formation
  • dna methylation
  • mass spectrometry
  • genetic diversity
  • genome wide analysis