HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis.
Elisabetta CaselliMaria D'AccoltiIrene SoffrittiMaria Chiara ZatelliRoberta RossiEttore Degli UbertiDario Di LucaPublished in: Virology journal (2017)
HHV-6A infection modulates miRNAs expression in the cell types involved in the development of AITD. Notably, our in vitro findings correlate with what observed in AITD patients, further supporting the association between HHV-6A infection and AITD development. Moreover, these effects are 6A-specific, emphasizing the differences between the two HHV-6 virus species, and suggesting diverse virus mechanisms of action and therapeutic approaches.