B7-H3 Expression in Merkel Cell Carcinoma-Associated Endothelial Cells Correlates with Locally Aggressive Primary Tumor Features and Increased Vascular Density.
Phyu P AungEdwin Roger Parra CuentesSouptik BaruaDawen SuiJing NingBarbara MinoDebora Alejandra LedesmaJonathan L CurryPriyardhisini NagarajanCarlos A Torres-CabalaEleni EfstathiouAnh G HoangMichael K WongJennifer A WargoAlexander J F LazarArvind RaoVictor G PrietoIgnacio WistubaMichael T TetzlaffPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Our results demonstrate that colocalized expression of B7-H3/CD31 is a poor prognostic indicator and suggest therapies targeting B7-H3 may represent an effective approach to augmenting immune-activating therapies for MCC.