IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease.
Beatriz Piantoni GonçalvesTamires FlauzinoCláudia Junko InoueJaqueline Costa Castardo de PaulaTalita Cristina GalvãoCamila Cataldi de AlcantaraPaula Kikuchi MiyazakiLucilene RosaSilva WestmoreMarcell Alysson Batisti LozovoyEdna Maria Vissoci ReicheAndréa Name Colado SimãoPublished in: International journal of colorectal disease (2020)
The G/C haplotype (recessive model) was associated with susceptibility to UC but not to CD. However, the G/C haplotype (dominant model) was associated with the endoscopic activity of CD. Moreover, these IL6 variants did not predict the TNF-α inhibitor therapy response.
Keyphrases
- disease activity
- rheumatoid arthritis
- patients with inflammatory bowel disease
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- stem cells
- nk cells
- intellectual disability
- gene expression
- autism spectrum disorder
- mesenchymal stem cells
- cell therapy
- smoking cessation
- muscular dystrophy
- duchenne muscular dystrophy