Survivin Small Molecules Inhibitors: Recent Advances and Challenges.
Najah AlbadariWei LiPublished in: Molecules (Basel, Switzerland) (2023)
Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a suppressor of apoptosis and plays a central role in cell division. Survivin has been considered as an important cancer drug target because it is highly expressed in many types of human cancers, while it is effectively absent from terminally differentiated normal tissues. Moreover, survivin is involved in tumor cell resistance to chemotherapy and radiation. Preclinically, downregulation of survivin expression or function reduced tumor growth induced apoptosis and sensitized tumor cells to radiation and chemotherapy in different human tumor models. This review highlights the role of survivin in promoting cellular proliferation and inhibiting apoptosis and summarizes the recent advances in and challenges of developing small-molecule survivin inhibitors.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- oxidative stress
- signaling pathway
- small molecule
- endothelial cells
- cell death
- cell cycle arrest
- single cell
- gene expression
- locally advanced
- cell therapy
- squamous cell carcinoma
- cell proliferation
- induced pluripotent stem cells
- radiation induced
- pluripotent stem cells
- young adults
- rectal cancer
- drug induced