Evidence of latent molecular diversity determining the virulence of community-associated MRSA USA300 clones in mice.
Shiro SonodaTetsuo YamaguchiKotaro AokiDaisuke OnoAyami SatoChiaki KajiwaraSoichiro KimuraYoshikiyo AkasakaYoshikazu IshiiYasunari MiyazakiNaohiko InaseKazuhiro TatedaPublished in: Immunity, inflammation and disease (2018)
The present data demonstrated latent diversity in the virulence of USA300 clones. Unknown regulatory mechanisms, probably involving a host factor(s) as a trigger, may govern the virulence expression and resultant high mortality in certain sub-clones of USA300.
Keyphrases
- staphylococcus aureus
- pseudomonas aeruginosa
- escherichia coli
- antimicrobial resistance
- biofilm formation
- poor prognosis
- methicillin resistant staphylococcus aureus
- transcription factor
- electronic health record
- cystic fibrosis
- cardiovascular events
- risk factors
- type diabetes
- binding protein
- metabolic syndrome
- skeletal muscle
- coronary artery disease
- long non coding rna
- single molecule
- candida albicans
- artificial intelligence