Glucose lowering drug or strategy dependent impact of weight reduction on the prevention of CVD outcomes in Type 2 diabetes: a systematic review of CVOTs.
Nebojša M LalićAleksandra JotićLjiljana LukićTanja MiličićMarija MaćešićJelena Stanarčić GajovićMilica StoiljkovićMina MilovančevićDjurdja Rafailović CvetkovićKatarina LalićPublished in: Diabetes research and clinical practice (2024)
In CVOTs, treatment of T2D patients resulted in BWL, which correlated with reduction in risk for CV outcomes, particularly with GLP-1 RAs. However, interventional non-CVOTs are warning that in the absence of structured behavioral intervention and relevant medication, the large BWL might be harmful for CV outcomes.