A boost in learning by removing nuclear phosphodiesterases and enhancing nuclear cAMP signaling.

cAMP signaling in the nucleus leads to the expression of immediate early genes in neurons and learning and memory. In this issue of Science Signaling , Martinez et al . found that activation of the β 2 -adrenergic receptor enhances nuclear cAMP signaling that supports learning and memory in mice by removing the phosphodiesterase PDE4D5 from the nucleus through arrestin3 bound to the internalized receptor.