Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis.

Gwénaël Le TeuffNathalie CozicJean-Christophe BoyerValérie BoigeRobert B DiasioGilles ManceauDidier MeulendijksClaire PallesMatthias SchwabMaarten DeenenCarlo R LargiadèrAnthony MarinakiBarbara A JenningsYvonne WettergrenAntonello Di PaoloEva GrossBarna BudaiStephen P AcklandAndré B P van KuilenburgHoward L McLeod Gerard MilanoFabienne ThomasMarie-Anne LoriotDavid J KerrJan H M SchellensPierre Laurent-PuigQian ShiJean-Pierre PignonMarie-Christine Etienne-Grimaldinull null

Published in: British journal of cancer (2024)

FUSAFE meta-analysis highlights the major relevance of DPYD *2A/p.D949V/*13 combined with clinical variables to identify patients at risk of very severe FP-related toxicity.

Keyphrases

systematic review
meta analyses
copy number
oxidative stress
drug induced
diabetic rats
randomized controlled trial
early onset
electronic health record
genome wide
high glucose
gene expression
big data
dna methylation
stress induced