Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy.
Gunasekaran SubramaniamKatharina SchleicherDuangnapa KovanichAnna ZerioMilda FolkmanaiteYing-Chi ChaoNicoletta C SurdoAndreas KoschinskiJianshu HuArjen ScholtenAlbert J R HeckMaria ErcuAnastasiia SholokhKyung Chan ParkAnastasiia SholokhViviana MeravigliaMilena BellinSara ZanivanSvenja HesterShabaz MohammedManuela ZaccoloPublished in: Circulation research (2023)
We developed a strategy for detailed mapping of subcellular PDE-specific cAMP nanodomains. Our findings reveal a mechanism that explains the negative long-term clinical outcome observed in patients with heart failure treated with PDE3 inhibitors.