Nutrition, DNA methylation and obesity across life stages and generations.
Anat Yaskolka MeirHuan YunMeir J StampferLiming LiangFrank B HuPublished in: Epigenomics (2023)
Obesity is a complex multifactorial condition that often manifests in early life with a lifelong burden on metabolic health. Diet, including pre-pregnancy maternal diet, in utero nutrition and dietary patterns in early and late life, can shape obesity development. Growing evidence suggests that epigenetic modifications, specifically DNA methylation, might mediate or accompany these effects across life stages and generations. By reviewing human observational and intervention studies conducted over the past 10 years, this work provides a comprehensive overview of the evidence linking nutrition to DNA methylation and its association with obesity across different age periods, spanning from preconception to adulthood and identify future research directions in the field.
Keyphrases
- dna methylation
- weight loss
- insulin resistance
- metabolic syndrome
- physical activity
- early life
- high fat diet induced
- weight gain
- type diabetes
- gene expression
- genome wide
- randomized controlled trial
- public health
- healthcare
- endothelial cells
- mental health
- depressive symptoms
- birth weight
- pregnancy outcomes
- body mass index
- preterm birth
- pregnant women
- risk factors
- social media