The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium.

Chaker SlaymiEmmanuel VignalGaëlle CrèsPierre RouxAnne BlangyPeggy RaynaudPhilippe Fort

Published in: Biology of the cell (2019)

RhoU negatively controls cell growth in the intestinal epithelium. Since its expression is sensitive to non-canonical Wnt signals and is reduced in colorectal tumours, downregulating RhoU may thus have an instrumental role in tumour progression.

Keyphrases

cell proliferation
poor prognosis
oxidative stress
cell cycle
cell cycle arrest
endoplasmic reticulum stress
pi k akt
cell death
binding protein
long non coding rna
signaling pathway