Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance.
Jamaal L JamesBrandie C TaylorMargaret L AxelrodXiaopeng SunLindsey N GuerinPaula I Gonzalez-EricssonYu WangVioleta SanchezCatherine C FaheyMelinda E SandersYaomin XuEmily HodgesDouglas B JohnsonJustin M BalkoPublished in: Journal for immunotherapy of cancer (2023)
, the master regulator of MHC-II. These insights shed light on the molecular mechanisms involved in tsMHC-II suppression and highlight the potential of targeting EZH2 as a therapeutic strategy to improve immunotherapy efficacy.