Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs).

Michael C HeinrichJanice PattersonCarol BeadlingYuexiang WangMaria Debiec-RychterBarbara DewaeleChristopher L CorlessAnette DuensingChandrajit P RautBrian RubinTamas OrdogMatt van de RijnJerry CallThomas MühlenbergJonathan A FletcherSebastian Bauer

Published in: Clinical sarcoma research (2019)

Our results demonstrate that genomic events targeting cell cycle-related genes are associated with GIST progression to malignant disease. Based on this data, we propose a model for molecular pathogenesis of malignant GIST.

Keyphrases

cell cycle
copy number
cell proliferation
genome wide
electronic health record
cancer therapy
big data
gene expression
dna methylation
single molecule
drug delivery
artificial intelligence
transcription factor