Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis.

Katsuya NagaokaKousuke OgawaChengcheng JiKevin Y CaoXuewei BaiJoud MullaZhixiang ChengJack R WandsChiung-Kuei Huang

Published in: Digestive diseases and sciences (2020)

ASPH may modulate cholangiocarcinoma metastasis via matrix metalloproteinases expression. Taken together, targeting ASPH function may inhibit intrahepatic cholangiocarcinoma metastasis and improve survival.

Keyphrases

drug delivery
small molecule
poor prognosis
signaling pathway
protein protein
long non coding rna