Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia.

Isabel JiménezBárbara Tazón-VegaPau AbrisquetaJuan C NietoSabela BobilloCarles Palacio-GarcíaJúlia CarabiaRafael Valdés-MasMagdalena MunueraLluís PuigdefàbregasGenís ParraAnna Esteve-CodinaClara Franco-JaravaGloria IacoboniMaría José TerolJosé Antonio García-MarcoMarta CrespoFrancesc Bosch

Published in: Biomarker research (2021)

Altogether, we demonstrate that the interaction with the immune microenvironment plays a key role in clinical progression in CLL, thereby providing a rationale for the use of early immunotherapeutic intervention.

Keyphrases

chronic lymphocytic leukemia
randomized controlled trial

clinical trial

genome wide

dna methylation