Effects of Breast Cancer Adjuvant Chemotherapy Regimens on Expression of the Aging Biomarker, p16INK4a.

Shlomit S ShacharAllision M DealKatherine E Reeder-HayesKirsten A NyropNatalia MitinCarey K AndersLisa Anne CareyE Claire DeesTrevor A Jolly Gretchen G KimmickMeghan S KaruturiRaquel E ReinboltJoEllen C SpecaHyman B Muss

Published in: JNCI cancer spectrum (2020)

Our findings suggest that the aging effects of chemotherapy may be influenced by both chemotherapy type and the patient's baseline p16INK4a level. Measurement of p16INK4a expression is not currently available in the clinic, but nonanthracycline regimens offering similar efficacy as anthracycline regimens might be favored.

Keyphrases

poor prognosis
locally advanced
primary care
binding protein
case report
long non coding rna
young adults
rectal cancer