A multimodal MRI-based classification signature emerges just prior to symptom onset in frontotemporal dementia mutation carriers.
Rogier A FeisMark J R J BoutsFrank de VosTijn M SchoutenJessica L PanmanLize C JiskootElise G P DopperJeroen van der GrondJohn Cornelis van SwietenSerge A R B RomboutsPublished in: Journal of neurology, neurosurgery, and psychiatry (2019)
Our findings imply that presymptomatic FTD mutation carriers may remain similar to controls in terms of MRI-based classification scores until they are close to symptom onset. This proof-of-concept study shows the promise of longitudinal MRI data acquisition in combination with machine learning to contribute to early FTD diagnosis.