Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis.
Laura AtehortúaMauricio RojasGloria VásquezCarlos H Muñoz-VahosAdriana Vanegas-GarcíaRafael Andrés Posada-DuqueDiana CastañoPublished in: Arthritis research & therapy (2019)
MPs and MPs-ICs from patients with SLE and RA increase adhesion molecules expression, chemokine production, and structural alterations in macrovascular and microvascular endothelial cells. Therefore, high counts of these vesicles in patients would promote endothelial alterations and secondary tissue leukocyte infiltration.
Keyphrases
- endothelial cells
- rheumatoid arthritis
- disease activity
- end stage renal disease
- systemic lupus erythematosus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- poor prognosis
- prognostic factors
- ankylosing spondylitis
- peritoneal dialysis
- interstitial lung disease
- patient reported outcomes
- long non coding rna
- cystic fibrosis