Update on the management of gastric varices.
Xuefeng LuoVirginia Hernández-GeaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Gastro-oesophageal varices are the major clinical manifestations of cirrhosis and portal hypertension. Although less frequent than oesophageal varices (EV), bleeding from gastric varices (GV) is generally more severe and associated with higher mortality and a greater risk to rebleed. According to Sarin's classification, GVs are categorized into four types based on their location within the stomach and relationship with EV. Currently, treatment options for the management of GV include beta-blockers, endoscopic band ligation, endoscopic cyanoacrylate injection, EUS-guided coil/cyanoacrylate injection, transjugular intrahepatic portosystemic shunts and balloon-occluded retrograde transvenous obliteration. The best treatment strategy of GV remains controversial because of the heterogeneity of GV, lack of high-quality data and suboptimal trial design of the studies available. The proper treatment algorithm may require adequate endoscopic and imaging evaluation by a multidisciplinary team with multiple treatment options available. This review describes the hemodynamic features of GV, pharmacological, endoscopic and interventional radiological treatment options for GV.
Keyphrases
- ultrasound guided
- fine needle aspiration
- machine learning
- deep learning
- blood pressure
- high resolution
- clinical trial
- palliative care
- type diabetes
- atrial fibrillation
- cardiovascular disease
- randomized controlled trial
- risk factors
- single cell
- combination therapy
- phase iii
- artificial intelligence
- data analysis
- phase ii
- open label
- case control