A Multiscale Physiologically-Based Pharmacokinetic Model for Doxorubicin to Explore its Mechanisms of Cytotoxicity and Cardiotoxicity in Human Physiological Contexts.
Hua HeCan LiuYun WuXinyuan ZhangJianghong FanYanguang CaoPublished in: Pharmaceutical research (2018)
A multiscale PBPK model for doxorubicin was developed and further applied to explore its cytotoxic and cardiotoxic mechanisms.