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Pan-cancer Analysis of Homologous Recombination Repair-associated Gene Alterations and Genome-wide Loss of Heterozygosity Score.

Benedikt WestphalenAlexander D FineFabrice AndreShridar GanesanVolker HeinemannEtienne RouleauClare TurnbullLuis Garcia PalaciosJorge Antonio LopezEthan S SokolJoaquin Mateo
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Biallelic alterations in core HRR-associated genes are frequent, strongly associated with elevated gLOH, and enriched in breast, ovarian, pancreatic, and prostate cancer. This analysis could inform the design of the next generation of clinical trials examining DNA repair-targeting agents, including poly-ADP ribose polymerase inhibitors.
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