Vaccine effectiveness of the pneumococcal polysaccharide and conjugated vaccines in elderly and high-risk populations in preventing invasive pneumococcal disease: a systematic search and meta-analysis.

Melina Gade SikjaerAndreas Arnholdt PedersenMari Stenvold WikSynne Smith StensholtOle HilbergAnders Løkke

Published in: European clinical respiratory journal (2023)

The results from this review show a reduction of IPD in elderly and high-risk populations vaccinated with PPV23 and PCV13. The protective effect may be lower in elderly individuals aged >80 and in individuals with comorbidities. However, the literature is sparse; large-scale prospective studies are required to evaluate the VE of PPV23 and PCV13 vaccination in adults against IPD.

Keyphrases

middle aged
community dwelling
systematic review
randomized controlled trial
photodynamic therapy
genetic diversity
water soluble