Changing rate of serious infections in biologic-exposed rheumatoid arthritis patients. Data from South American registries BIOBADABRASIL and BIOBADASAR.
Roberto RanzaMaria Celina de la VegaIeda Maria Magalhães LaurindoMarìa Gimena GómezDavid Cezar TittonAdriana Maria KakehasiAlejandro BriganteAlejandro BenitezAline RanzolinAmelia GranelAna María CappuccioAna QuinterosAndré Luiz Shinji HayataAndrea SmichowskiÂngela Luzia Branco P DuarteBarbara Stadler KahlowCarolina Sánchez AndiaClaiton Viegas BrenolEdson VelozoEduardo MussanoEnrique R SorianoGeorges Basile ChristopoulosGeraldo da Rocha Castelar PinheiroGláucio Ricardo Werner de CastroGustavo CasadoHellen Mary da Silveira CarvalhoIda Elena ExeniInês Guimarães da SilveiraIngrid PetkovicIvanio Alves PereiraIzaias Pereira da CostaJavier Eduardo RosaJosé Roberto Silva MirandaJulio Cesar Bertacini de MoraesManoel Barros BertoloManuel BuhlMaria Alícia LázaroMaria de Fátima Lobato C da SaumaMarcelo de Medeiros PinheiroMonica DíazMônica Valéria Siqueira Santana de VechiOsvaldo Luis CerdaPablo AstesanaPablo Finucci CuriPaulo Louzada-JrReginaldo Botelho TeodoroRoberto Acayaba ToledoSílvia PapasideroValeria ValimVander FernandesVeronica SauritWashington Alves Bianchinull nullRogério de Melo Costa PintoMiguel Angel DescalzoJuan Jesus Gomez-ReinoPublished in: Clinical rheumatology (2019)
While SI remains a major concern in South American patients with RA treated with bDMARDs, a favourable trend toward a reduction was observed in the last years.Key Points• New comprehensive data on biologic drugs safety from international collaboration in South America.• First proposal for national registries data merging in South America.• Serious infections remain a major concern in RA patients treated with biologics.• A significant reduction of serious infections in RA patients exposed to biologics was observed over a 7 years period.
Keyphrases
- rheumatoid arthritis
- disease activity
- rheumatoid arthritis patients
- electronic health record
- end stage renal disease
- ankylosing spondylitis
- chronic kidney disease
- ejection fraction
- systemic lupus erythematosus
- interstitial lung disease
- quality improvement
- peritoneal dialysis
- prognostic factors
- systemic sclerosis
- idiopathic pulmonary fibrosis
- ionic liquid