Anti-PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells.
Maud RijndersHayri E BalciogluDebbie G J RobbrechtAstrid A M OostvogelsRebecca WijersMaureen J B AartsPaul HambergG J L H Geert van LeendersJosé Alberto Nakauma-GonzálezJens VoortmanHans M WestgeestJoost L BoormansRonald de WitMartijn Paul LolkemaAstrid A M van der VeldtReno DebetsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
A decrease in the fraction of circulating PD-1+ CD4+ T cells, and juxtaposition of Th1, CD8+, and myeloid cells was associated with response to anti-PD-1 treatment in patients with mUC.