Hypercalcaemia of malignancy: a case of vitamin-D-mediated hypercalcaemia in lymphoma.
Kanchi MehtaMaham AwanShannon DevlinSimerjot Kaur JassalPublished in: BMJ case reports (2024)
Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-(OH) 2 D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-(OH) 2 D 3 ), causing the patient's hypercalcaemia.
Keyphrases
- positron emission tomography
- pet ct
- computed tomography
- poor prognosis
- rare case
- diffuse large b cell lymphoma
- bone marrow
- case report
- abdominal pain
- long non coding rna
- pet imaging
- mesenchymal stem cells
- magnetic resonance imaging
- heart failure
- clinical trial
- dual energy
- ultrasound guided
- fine needle aspiration
- left ventricular
- atrial fibrillation