Ferroptosis of microglia in aging human white matter injury.

Philip A AdeniyiXi GongEllie MacGregorKiera Degener-O'BrienEvelyn McClendonMariel GarciaOscar RomeroJoshua RussellTaasin SrivastavaJeremy MillerC Dirk KeeneStephen A Back

Published in: Annals of neurology (2023)

Ferroptosis appears to be a major mechanism of white matter injury in Alzheimer's disease and vascular dementia. White matter DM are a novel therapeutic target to potentially reduce the impact of white matter injury and myelin loss on the progression of cognitive impairment. This article is protected by copyright. All rights reserved.

Keyphrases

white matter
cognitive impairment
multiple sclerosis
cell death
endothelial cells
mild cognitive impairment
cognitive decline
inflammatory response
type diabetes
neuropathic pain
induced pluripotent stem cells
spinal cord
weight loss
pluripotent stem cells