Stimulated Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteogenesis and Cranial Bone Regeneration through IL-32 Mediated P38 Signaling Pathway.
Xiaru ZhangYing ZhengGang WangYuanlin LiuYang WangXueyi JiangYueqing LiangXinfeng ZhaoPing LiYi ZhangPublished in: Stem cells international (2024)
We have confirmed that S-HuMSCs can enhance the osteogenesis and cranial bone regeneration through promoting IL-32-mediated P38 signaling pathway, which is proved that IL-32 may be a therapeutic target, or a biomarker for the treatment of cranial bone injuries.
Keyphrases
- bone regeneration
- mesenchymal stem cells
- umbilical cord
- signaling pathway
- pi k akt
- endothelial cells
- bone marrow
- epithelial mesenchymal transition
- induced apoptosis
- induced pluripotent stem cells
- cell therapy
- oxidative stress
- cell proliferation
- combination therapy
- pluripotent stem cells
- bone mineral density
- endoplasmic reticulum stress