Comprehensive evaluation of microneedle-based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial.
Justin JacobseWouter Ten VoordeAnushka TandonStefan G RomeijnHendrika W GrievinkKoen van der MaadenMichiel Joost van EsdonkDirk Jan A R MoesFloris LoeffKarien BloemAnnick de VriesTheo RispensGertjan WolbinkMarieke de KamDimitrios ZiagkosMatthijs MoerlandWim JiskootJoke BouwstraJacobus BurggraafLenneke SchrierRobert RissmannRebecca Ten CatePublished in: British journal of clinical pharmacology (2021)
Intradermal injection of adalimumab using hollowing microneedles was perceived as more painful and less accepted than s.c. administration, but yields a higher relative bioavailability with similar safety and pharmacodynamic effects.