The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
Silvia MatteoniClaudia AbbruzzesePaola MatarreseGabriele De LucaAnna M MileoStefania MiccadeiSilvia SchenoneFrancesca MusumeciTobias L HaasGiovanni SetteCarmine M CarapellaRosario AmatoNicola PerrottiMichele SignoreMarco G PaggiPublished in: Journal of experimental & clinical cancer research : CR (2019)
RPPA clearly identified the molecular pathways influenced by SI113 in GBM cells, highlighting their vulnerability when the drug was administered in association with autophagy inhibitors, providing a strong molecular rationale for testing SI113 in clinical trials in associative GBM therapy.