Pitavastatin stimulates retinal angiogenesis via HMG-CoA reductase-independent activation of RhoA-mediated pathways and focal adhesion.

Zhi LiJing ZhangYanni XueYing HeLanlan TangMin KeYan Gong

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2021)

Our work provides a preclinical evidence on the pro-angiogenic effect of pitavastatin in retina via multiple mechanisms that are irrelevant to mevalonate pathway.

Keyphrases

diabetic retinopathy
optic nerve
optical coherence tomography
endothelial cells
vascular endothelial growth factor
anti inflammatory
fatty acid
biofilm formation
cell therapy
stem cells
staphylococcus aureus
escherichia coli
mesenchymal stem cells
cell adhesion
cystic fibrosis