EGFR-AS1/HIF2A regulates the expression of FOXP3 to impact the cancer stemness of smoking-related non-small cell lung cancer.

Haolong QiShanshan WangJuekun WuShucai YangSteven GrayCalvin S H NgJing DuMalcolm J UnderwoodMing-Yue LiGeorge Gong Chen

Published in: Therapeutic advances in medical oncology (2019)

FOXP3, the expression of which is under the fine control of EGFR-AS1, is a critical molecule that promotes NSCLC cancer cell stemness through stimulating the Notch1 pathway.

Keyphrases

small cell lung cancer
poor prognosis
regulatory t cells
stem cells
epidermal growth factor receptor
epithelial mesenchymal transition
tyrosine kinase
papillary thyroid
binding protein
air pollution
long non coding rna
brain metastases
endothelial cells
dendritic cells
young adults
lymph node metastasis