Toll-Like Receptor 8 is Expressed in Monocytes in Contrast to Plasmacytoid Dendritic Cells and Mediates Aberrant Interleukin-10 Responses in Patients With Systemic Sclerosis.

Christine EhlersThea ThieleHannah BiermannStephan TraidlLuzia BrunsAnnett ZieglerMatthias SchefzykLea M BartschUlrich KalinkeTorsten WitteTheresa Graalmann

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

TLR8 protein is not expressed in pDCs of patients with SSc. Accordingly, they do not respond to TLR8 stimulation. In contrast, monocytes of patients with SSc respond to TLR8 stimulation with increased IL-10 responses. Therefore, TLR8 signaling in monocytes participates in SSc pathogenesis by conferring aberrant IL-10 expression.

Keyphrases

toll like receptor
dendritic cells
immune response
systemic sclerosis
inflammatory response
nuclear factor
regulatory t cells
interstitial lung disease
magnetic resonance
poor prognosis
contrast enhanced
binding protein
computed tomography
peripheral blood
rheumatoid arthritis
long non coding rna