Cobalt-Catalyzed Asymmetric 1,4-Hydroboration of Enones with HBpin.
Xiang RenZhan LuPublished in: Organic letters (2021)
Herein, a series of new 8-OIQ cobalt complexes were synthesized and used for cobalt-catalyzed chemo- and enantioselective 1,4-hydroboration of enones with HBpin to access chiral β,β-disubstituted ketones with good to excellent chemo- and enantioselectivties. This protocol is operationally simple and shows a broad substrate scope.
Keyphrases
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