The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening.
Maitee Rosende-RocaCarla AbdelnourEster EstebanJuan Pablo TartariEmilio AlarconJuliana Martínez-AtienzaAntonio González-PérezMaría E SáezAsunción LafuenteMar BuendíaAna PanchoNuria AguileraMarta IbarriaSusana DiegoSara JofresaIsabel HernándezRogelio LópezMiren Jone GurruchagaLluís TárragaSergi ValeroAgustín RuizMarta MarquiéMerce BoadaPublished in: Alzheimer's research & therapy (2021)
The large number of low-educated elderly women with AD demands for a sex-focused approach in clinical research. New assessment tools insensitive to education level should be developed to enable a proportional representation of women. Although this gender education gap is mostly inexistent in developed countries, economic or cultural factors may lead to different scenarios in other regions. Overlooking the impact of sex may lead to a handicap in AD research with a direct adverse impact on women's health.
Keyphrases
- healthcare
- clinical trial
- polycystic ovary syndrome
- end stage renal disease
- mental health
- ejection fraction
- newly diagnosed
- chronic kidney disease
- public health
- pregnancy outcomes
- climate change
- peritoneal dialysis
- quality improvement
- type diabetes
- randomized controlled trial
- prognostic factors
- metabolic syndrome
- breast cancer risk
- risk assessment
- middle aged
- pregnant women
- adverse drug
- insulin resistance
- electronic health record
- neural network