Sweet taste receptor agonists attenuate macrophage IL-1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells.

Jinju LeeSo Jeong KimGo Eun ChoiEunbi YiHyo Jin ParkWoo Seon ChoiYong Ju JangHyo Jung Lee

Published in: Clinical and translational medicine (2022)

Our results revealed a previously unappreciated anti-inflammatory effect of STR agonists, particularly trehalose and saccharin, and may provide an alternative strategy to autophagy modulation in the ECRS treatment.

Keyphrases

induced apoptosis
oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest
anti inflammatory
signaling pathway
poor prognosis
adipose tissue
dendritic cells
acute myeloid leukemia
single cell
long non coding rna
binding protein
cell proliferation