Acyclovir treatment of varicella-zoster virus meningeal infections and acute kidney injury: a multicentre case series study.

Myriam ContamineFlorence AderQuentin LepillerBenoit MarthaJoséphine Cagnon-ChapalainPaul LeturnierEmilie FroberKevin BouillerChristine BinquetChristelle AuvrayLionel PirothMathieu Blot

Published in: Infectious diseases (London, England) (2024)

Intravenous acyclovir is widely prescribed when VZV DNA is isolated in CSF, regardless of the clinical presentation, with a high rate of AKI. Further studies are needed to better define the value of intravenous acyclovir in isolated VZV meningitis.

Keyphrases

acute kidney injury
herpes simplex virus
cardiac surgery
high dose
clinical trial
cerebrospinal fluid
study protocol
randomized controlled trial
cell free
combination therapy