Age-dependent hypoxia-induced PD-L1 upregulation in patients with obstructive sleep apnoea.

Carolina Cubillos-ZapataCristina Balbás-GarcíaJose Avendaño-OrtizVictor ToledanoMarta TorresIsaac AlmendrosRaquel CasitasEster ZamarrónAldara García-SánchezJaime FeliuLuis A AguirreRamón FarreEduardo López-CollazoFrancisco García-Río

Published in: Respirology (Carlton, Vic.) (2019)

PD-L1 upregulation in patients with OSA as a consequence of HIF-1α activation occurs mainly in young patients. In older patients with OSA, upregulation was not detected, possibly due to impaired oxygen sensitivity.

Keyphrases

poor prognosis
end stage renal disease
obstructive sleep apnea
cell proliferation
positive airway pressure
signaling pathway
newly diagnosed
physical activity
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
long non coding rna
depressive symptoms
community dwelling