Sexual Dimorphism in Small-intestinal Neuroendocrine Tumors: Lower Prevalence of Mesenteric Disease in Premenopausal Women.
Anela BlaževićAnand M IyerMarie-Louise F van VelthuysenJohannes HoflandLindsey OudijkWouter W de HerderLeo J HoflandRichard A FeeldersPublished in: The Journal of clinical endocrinology and metabolism (2022)
Sexual dimorphism in SI-NETs was most pronounced in mesenteric disease, and the risk of mesenteric metastasis in women increased around menopause. The combination of increased ERα and AR expression in the SI-NET microenvironment suggests a modulating role of sex steroids in the development of the characteristic SI-NET mesenteric metastasis and associated fibrosis.