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Photoinduced Decatungstate Anion-Catalyzed 1,4-Difunctionalization of 1,3-Butadienes via C-H Activation.

Xiao-Yun RuanDan-Xing WuWen-Ao LiZihan LinMostafa SayedZhi-Yong HanLiu-Zhu Gong
Published in: Organic letters (2024)
This paper outlines an innovative three-component coupling strategy for the 1,4-difunctionalization of 1,3-butadiene, utilizing sodium decatungstate (NaDT) as a hydrogen atom transfer (HAT) photocatalyst. The photoinduced process efficiently generates homoallylic amino acid esters with 100% atom economy, employing readily available components under mild reaction conditions. This light-induced protocol eliminates the need for an additional transition metal catalysts, additives, or equivalent reducing agents. The study explored various C(sp 3 )-H bearing partners, butadienes, and α-iminoesters, demonstrating the versatility and synthetic utility of this method.
Keyphrases
  • electron transfer
  • transition metal
  • amino acid
  • highly efficient
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  • molecular dynamics
  • visible light
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