Multiple Sclerosis CSF Is Enriched With Follicular T Cells Displaying a Th1/Eomes Signature.

Jérémy MorilleMarion MandonStéphane RodriguezDavid RouloisSimon Leonard Alexandra GarciaSandrine WiertlewskiEmmanuelle Le PageLaureline BerthelotArnaud B NicotCamille MathéFlora LejeuneKarin TarteCéline DelaloyPatricia Amé-ThomasDavid LaplaudLaure Michel

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

Overall, CSF enrichment in activated Tfh1 as soon as disease diagnosis, associated with high expression of EOMES, and a predicted high propensity to interact with CSF B cells suggest that these cells probably contribute to disease onset and/or activity.

Keyphrases

multiple sclerosis
induced apoptosis
poor prognosis
cerebrospinal fluid
binding protein