A hypothesis: MiRNA-124 mediated regulation of sirtuin 1 and vitamin D receptor gene expression accelerates aging.

Poulami DharShailaja S MoodithayaPrakash PatilKellarai Adithi

Published in: Aging medicine (Milton (N.S.W)) (2024)

Overall, this study hypothesizes that the overexpression of miR-124 diminishes the expression of VDR and SIRT1 genes, and thereby advances the process of aging, resulting in the development of age-associated complications.

Keyphrases

gene expression
cell proliferation
poor prognosis
long non coding rna
dna methylation
genome wide
oxidative stress
risk factors
long noncoding rna
ischemia reperfusion injury
binding protein