Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women.
G OzenS BoumizaC DeschildreG TopalD LongroisP J JakobssonJ B MichelM P JacobK ChahedXavier NorelPublished in: International journal of obesity (2005) (2018)
The greater MMP activity observed in SV may contribute to the increased prevalence of graft failure. Under inflammation, the greater mPGES-1 and PGE2 levels lead to enhanced MMP activity in human vascular walls. The positive association between PGE2 and MMP-1 or CRP has been observed in plasma of women. We suggest that mPGES-1 inhibitors could prevent graft failure and obesity-related vascular remodeling mostly in women.
Keyphrases
- polycystic ovary syndrome
- endothelial cells
- oxidative stress
- cell migration
- metabolic syndrome
- pregnancy outcomes
- insulin resistance
- weight loss
- type diabetes
- cervical cancer screening
- adipose tissue
- induced pluripotent stem cells
- pluripotent stem cells
- breast cancer risk
- bariatric surgery
- physical activity
- skeletal muscle