Disulfiram enhances chemotherapeutic effects of doxorubicin liposomes against human hepatocellular carcinoma via activating ROS-induced cell stress response pathways.

Hai LinFengjie SunTingting LiYihan ZhangXiaochun GuoMing LiMin LiangXinke ZhouZhiyuan Fang

Published in: Cancer chemotherapy and pharmacology (2022)

Due to its low price and good safety, it is worth to repurposing disulfiram as a chemotherapeutic drug. Furthermore, MDM4 may act as a biomarker for observation the clinical effect of disulfiram-based treatment.

Keyphrases

drug delivery
endothelial cells
high glucose
single cell
cell death
signaling pathway
dna damage
cell therapy
diabetic rats
induced pluripotent stem cells
cancer therapy
pluripotent stem cells
drug release
mesenchymal stem cells
adverse drug